Low maternal vitamin A intake increases the incidence of teratogen induced congenital diaphragmatic hernia in mice
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چکیده
منابع مشابه
Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats.
Congenital diaphragmatic hernia (CDH) is a major cause of refractory respiratory failure in the newborn. Pulmonary hypoplasia often limits survival. Vitamin A (Vit A) is an important signal for lung growth. We hypothesized that antenatal treatment with Vit A would stimulate lung growth and decrease mortality in experimental CDH induced in rats by ingestion of the herbicide nitrofen (2,4-dichlor...
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Congenital diaphragmatic hernia (CDH) is a serious medical condition in which the developing diaphragm forms incompletely, leaving a hole through which the abdominal contents can enter the thoracic space and interfere with lung growth. A perturbation of the retinoid system has been linked to the etiology of CDH. This includes findings that nitrofen, which induces CDH in rodents, inhibits the ke...
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Congenital diaphragmatic hernia (CDH) is a developmental anomaly that results in significant mortality and morbidity. The underlying etiology is poorly understood. Insights will arise from an understanding of the mechanisms by which the teratogen nitrofen induces CDH in rodent models. In this study, we use in vitro cell assays in conjunction with whole animal rodent studies to test hypotheses r...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2021
ISSN: 0031-3998,1530-0447
DOI: 10.1038/s41390-021-01409-6